ea0020p9 | Adrenal | ECE2009
Debono Miguel
, Ghobadi Cyrus
, Rostami-Hodjegan Amin
, Huatan Hiep
, Campbell Mike
, Newell-Price John
, Darzy Ken
, Merke DeborahP
, Arlt Wiebke
, Ross Richard
Background: The adrenal glucocorticoid, cortisol, has a distinct circadian rhythm regulated by the brains central pacemaker. This cortisol rhythm acts as a secondary messenger to peripheral tissues and loss of the rhythm is associated with increased morbidity and mortality. This is a specific problem in adrenal insufficiency and congenital adrenal hyperplasia (CAH). Based on pharmacokinetic modelling we have developed a modified-release formulation of hydrocortisone (MR-...